Ontology highlight
ABSTRACT:
SUBMITTER: Collman R
PROVIDER: S-EPMC240461 | biostudies-other | 1992 Dec
REPOSITORIES: biostudies-other
Journal of virology 19921201 12
We isolated and molecularly cloned a human immunodeficiency virus type 1 (HIV-1) strain (89.6) which is unusual because it is both macrophage-tropic and extremely cytopathic in lymphocytes. Moreover, this is the first well-characterized infectious molecularly cloned macrophage-tropic HIV-1 strain derived from peripheral blood. HIV-1 89.6 differs markedly from other macrophage-tropic isolates within the envelope V3 region, which is important in determining cell tropism and cytopathicity. HIV-1 89 ...[more]