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Nuclear survivin as a biomarker for non-small-cell lung cancer.


ABSTRACT: Survivin inhibits apoptosis and promotes mitosis. We determined whether nuclear or cytoplasmic localisation of survivin predicts survival of 48 patients with resected non-small-cell lung cancer (NSCLC). Patients with nuclear staining of survivin had significantly worse survival (relative risk: 3.9, P=0.02). Therefore, survivin may be a biomarker for NSCLC.

SUBMITTER: Lu B 

PROVIDER: S-EPMC2409840 | biostudies-other | 2004 Aug

REPOSITORIES: biostudies-other

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