Unknown

Dataset Information

0

Increased frequency of the k-ras G12C mutation in MYH polyposis colorectal adenomas.


ABSTRACT: Colorectal tumours from MYH polyposis patients display an excess of somatic G : C --> T : A transversions in the adenomatous polyposis coli gene. Here, we identify k-ras mutations in nine out of 54 (16.7%) MYH polyposis tumours. Their presence was associated with increased dysplasia and tubulovillous morphology (P=0.005). G : C --> T : A transversions in k-ras were significantly more frequent in MYH polyposis adenomas than in sporadic or familial adenomatous polyposis-associated tumours (P

SUBMITTER: Jones S 

PROVIDER: S-EPMC2410274 | biostudies-other | 2004 Apr

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC122454 | biostudies-literature
| S-EPMC3407043 | biostudies-literature
| S-EPMC4511034 | biostudies-literature
| S-EPMC6588610 | biostudies-literature
| S-EPMC8629245 | biostudies-literature
| S-EPMC1727113 | biostudies-other
| S-EPMC2966613 | biostudies-literature
| S-EPMC8315898 | biostudies-literature
| S-EPMC7541019 | biostudies-literature
| S-EPMC6135695 | biostudies-literature