Glycoprotein H of pseudorabies virus is essential for entry and cell-to-cell spread of the virus.
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ABSTRACT:
SUBMITTER: Peeters B
PROVIDER: S-EPMC241176 | biostudies-other | 1992 Jun
REPOSITORIES: biostudies-other
Publications
Glycoprotein H of pseudorabies virus is essential for entry and cell-to-cell spread of the virus.
Peeters B B de Wind N N Broer R R Gielkens A A Moormann R R
Journal of virology 19920601 6
To study the function of the envelope glycoprotein gH of pseudorabies virus, a gH null mutant was constructed. A premature translation termination codon was introduced in the gH gene by linker insertion mutagenesis, and a mutant virus was rescued by using a cell line that expresses the wild-type protein. Mutant virus isolated from complementing cells was unable to form plaques on noncomplementing cells, indicating that gH is essential in the life cycle of the virus. Immunological staining and el ...[more]
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