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Cytomegalovirus homologs of cellular G protein-coupled receptor genes are transcribed.


ABSTRACT: The genome of human cytomegalovirus (HCMV) contains three genes with homology to cellular G protein-coupled receptors (GCRs). Evidence is presented here that all three HCMV GCR genes are transcribed during infection, that they are transcribed as two sets of 3'-coterminal mRNAs, and that their transcription is restricted to the late phase of infection.

SUBMITTER: Welch AR 

PROVIDER: S-EPMC241428 | biostudies-other | 1991 Jul

REPOSITORIES: biostudies-other

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Cytomegalovirus homologs of cellular G protein-coupled receptor genes are transcribed.

Welch A R AR   McGregor L M LM   Gibson W W  

Journal of virology 19910701 7


The genome of human cytomegalovirus (HCMV) contains three genes with homology to cellular G protein-coupled receptors (GCRs). Evidence is presented here that all three HCMV GCR genes are transcribed during infection, that they are transcribed as two sets of 3'-coterminal mRNAs, and that their transcription is restricted to the late phase of infection. ...[more]

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