Four-dimensional analysis of vascularization during primary development of an organ, the gonad.
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ABSTRACT:
SUBMITTER: Coveney D
PROVIDER: S-EPMC2438229 | biostudies-other | 2008 May
REPOSITORIES: biostudies-other
Publications
Four-dimensional analysis of vascularization during primary development of an organ, the gonad.
Coveney Douglas D Cool Jonah J Oliver Tim T Capel Blanche B
Proceedings of the National Academy of Sciences of the United States of America 20080514 20
Time-lapse microscopy has advanced our understanding of yolk sac and early embryonic vascularization. However, it has been difficult to assess endothelial interactions during epithelial morphogenesis of internal organs. To address this issue we have developed the first time-lapse system to study vascularization of a mammalian organ in four dimensions. We show that vascularization of XX and XY gonads is a highly dynamic, sexually dimorphic process. The XX gonad recruits vasculature by a typical a ...[more]
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