Ontology highlight
ABSTRACT:
SUBMITTER: Do H
PROVIDER: S-EPMC2442881 | biostudies-other | 2008
REPOSITORIES: biostudies-other
Do Hongdo H Solomon Benjamin B Mitchell Paul L PL Fox Stephen B SB Dobrovic Alexander A
BMC research notes 20080516
<h4>Background</h4>A recurrent somatic mutation, E17K, in the pleckstrin homology domain of the AKT1 gene, has been recently described in breast, colorectal, and ovarian cancers. AKT1 is a pivotal mediator of signalling pathways involved in cell survival, proliferation and growth. The E17K mutation stimulates downstream signalling and exhibits transforming activity in vitro and in vivo.<h4>Findings</h4>We developed a sensitive high resolution melting (HRM) assay to detect the E17K mutation from ...[more]