Ontology highlight
ABSTRACT:
SUBMITTER: Cuppen E
PROVIDER: S-EPMC2447299 | biostudies-other | 2003
REPOSITORIES: biostudies-other
Cuppen Edwin E van der Linden Alexander M AM Jansen Gert G Plasterk Ronald H A RH
Comparative and functional genomics 20030101 5
To identify novel components in heterotrimeric G-protein signalling, we performed an extensive screen for proteins interacting with Caenorhabditis elegans Galpha subunits. The genome of C. elegans contains homologues of each of the four mammalian classes of Galpha subunits (Gs, Gi/o, Gq and G12), and 17 other Galpha subunits. We tested 19 of the GGalpha subunits and four constitutively activated Galpha subunits in a largescale yeast two-hybrid experiment. This resulted in the identification of 2 ...[more]