Pathway analysis reveals functional convergence of gene expression profiles in breast cancer.
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ABSTRACT:
SUBMITTER: Shen R
PROVIDER: S-EPMC2447843 | biostudies-other | 2008 Jun
REPOSITORIES: biostudies-other
Publications
Pathway analysis reveals functional convergence of gene expression profiles in breast cancer.
Shen Ronglai R Chinnaiyan Arul M AM Ghosh Debashis D
BMC medical genomics 20080627
<h4>Background</h4>A recent study has shown high concordance of several breast-cancer gene signatures in predicting disease recurrence despite minimal overlap of the gene lists. It raises the question if there are common themes underlying such prediction concordance that are not apparent on the individual gene-level. We therefore studied the similarity of these gene-signatures on the basis of their functional annotations.<h4>Results</h4>We found the signatures did not identify the same set of ge ...[more]
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