Ontology highlight
ABSTRACT:
SUBMITTER: Utley TJ
PROVIDER: S-EPMC2481327 | biostudies-other | 2008 Jul
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 20080709 29
Respiratory syncytial virus (RSV) infects polarized epithelia, which have tightly regulated trafficking because of the separation and maintenance of the apical and basolateral membranes. Previously we established a link between the apical recycling endosome (ARE) and the assembly of RSV. The current studies tested the role of a major ARE-associated protein, Rab11 family interacting protein 2 (FIP2) in the virus life cycle. A dominant-negative form of FIP2 lacking its N-terminal C2 domain reduced ...[more]