Early polyethylene wear and excessive acetabular granuloma in an uncemented HA-coated total hip arthroplasty--midterm results of a prospective study.
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ABSTRACT:
SUBMITTER: Ohnsorge JA
PROVIDER: S-EPMC2488178 | biostudies-other | 2006 Sep
REPOSITORIES: biostudies-other
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Project description:UNLABELLED: Restoration of femoral offset and acetabular inclination may have an effect on polyethylene (PE) wear in THA. We therefore assessed the effect of femoral offset and acetabular inclination (angle) on acetabular conventional (not highly cross-linked) PE wear in uncemented THA. We prospectively followed 43 uncemented THAs for a minimum of 49 months (mean, 64 months; range, 49-88 months). Radiographs were assessed for femoral offset, acetabular inclination, and conventional PE wear. The mean (+/- standard deviation) linear wear rate in all THAs was 0.14 mm/year (+/- 0.01 mm/year) and the mean volumetric wear rate was 53.1 mm(3)/year (+/- 5.5 mm(3)/year). In THAs with an acetabular angle less than 45 degrees , the mean wear was 0.12 mm/year (+/- 0.01 mm/year) compared with 0.18 mm/year (+/- 0.02 mm/year) in those with a reconstructed acetabular angle greater than 45 degrees . Reproduction of a reconstructed femoral offset to within 5 mm of the native femoral offset was associated with a reduction in conventional PE wear (0.12 mm/year versus 0.16 mm/year). Careful placement of the acetabular component to ensure an acetabular angle less than 45 degrees in the reconstructed hip allows for reduced conventional PE wear. LEVEL OF EVIDENCE: Level II, prospective study. See Guidelines for Authors for a complete description of levels of evidence.
| S-EPMC2758973 | biostudies-other
Project description:Background and purpose - Backside wear of the polyethylene insert in total knee arthroplasty (TKA) can produce clinically significant levels of polyethylene debris, which can lead to loosening of the tibial component. Loosening due to polyethylene debris could theoretically be reduced in tibial components of monoblock polyethylene design, as there is no backside wear. We investigated the effect of 2 different tibial component designs, monoblock and modular polyethylene, on migration of the tibial component in uncemented TKA. Patients and methods - In this randomized study, 53 patients (mean age 61 years), 32 in the monoblock group and 33 in the modular group, were followed for 2 years. Radiostereometric analysis (RSA) was done postoperatively after weight bearing and after 3, 6, 12, and 24 months. The primary endpoint of the study was comparison of the tibial component migration (expressed as maximum total point motion (MTPM)) of the 2 different implant designs. Results - We did not find any statistically significant difference in MTPM between the groups at 3 months (p = 0.2) or at 6 months (p = 0.1), but at 12 and 24 months of follow-up there was a significant difference in MTPM of 0.36 mm (p = 0.02) and 0.42 mm (p = 0.02) between groups, with the highest amount of migration (1.0 mm) in the modular group. The difference in continuous migration (MTPM from 12 and 24 months) between the groups was 0.096 mm (p = 0.5), and when comparing MTPM from 3-24 months, the difference between the groups was 0.23 mm (p = 0.07). Interpretation - In both study groups, we found the early migration pattern expected, with a relatively high initial amount of migration from operation to 3 months of follow-up, followed by stabilization of the implant with little migration thereafter. However, the modular implants had a statistically significantly higher degree of migration compared to the monoblock. We believe that the greater stiffness of the modular implants was the main reason for the difference in migration, but an initial creep in the polyethylene metal-back locking mechanism of the modular group could also be a possible explanation for the observed difference in migration between the 2 study groups.
| S-EPMC5119444 | biostudies-literature
Project description:Background and purpose - The long-term survival of arthroplasty components may be limited by polyethylene wear-related problems such as periprosthetic osteolysis and aseptic loosening. Highly cross-linked polyethylene (HXLPE) blended with vitamin E was introduced to improve oxidative stability and to avoid long-term embrittlement. This study clinically compares the tribological behavior and clinical outcome of vitamin E blended HXLPE with ultra-high molecular weight polyethylene (UHMWPE) in an isoelastic monoblock cup for uncemented total hip arthroplasty.Patients and methods - In this randomized controlled trial (RCT), 199 patients were included: 102 patients received the vitamin E blended HXLPE cup, 97 patients the UHMWPE cup. Clinical and radiographic parameters were obtained preoperatively, directly postoperative and at 3, 12, and 24 months. Wear rates were compared using the mean linear femoral head penetration (FHP) rate.Results - 188 patients (94%) completed the 2-year follow-up. Mean patient satisfaction was higher in the vitamin E blended HXLPE group (8.9 [1]) than in in the control group (8.5 [2], p = 0.03). The Harris Hip Score (HHS) was higher in the vitamin E blended HXLPE group (95 [8]) than in the control group (92 [11], p = 0.3). The FHP rate was lower in the vitamin E blended HXLPE group: 0.046 mm/year compared with 0.056 mm/year in the control group (p = 0.05). No adverse reactions associated with the clinical application of vitamin E blended HXLPE were observed during follow-up, with an excellent 2-year survival to revision rate of 98% for both cups.Interpretation - This study shows the superior performance of the HXLPE blended with vitamin E acetabular cup with lower linear femoral head penetration rates and better clinical results compared with the UHMWPE acetabular cup after 2 years.
| S-EPMC8023900 | biostudies-literature
Project description:Uncemented acetabular components have demonstrated low revision rates and high patient satisfaction but with concerns regarding increased costs compared with monoblock cups. Some newer lower-cost uncemented monoblock options have become available in the last decade, but limited data are available on their performance.(1) Does an uncemented, titanium-backed all-polyethylene acetabular cup provide reliable fixation? (2) What is the frequency and what are the causes for revision with this cup?Between 2004 and 2008, we elected to use an uncemented, titanium-backed all-polyethylene acetabular cup in older patients with limited physical demands. We performed 615 hip replacements in 550 patients with greater than 5 years of clinical and radiographic followup. When patients who were dead (80 hips in 75 patients), lost to followup (98 hips in 93 patients), or revised (three hips in three patients) were excluded, there were 434 hips in 379 patients for comparison of the postoperative and 5-year radiographs. Two observers not involved in the index surgical procedures (NH, HS) assessed radiographs for signs of migration or loosening. Some degree of early movement sometimes is seen before cup stabilization; however, to be conservative, we defined cups with greater than 3° of change of position (even if they subsequently stabilized) as potentially at risk and report them separately. Revision surgery, time from the index procedure, and the reason for revision were recorded from the New Zealand Joint Registry.By 5 years there was a median change in inclination of 2° (range, 0°-13°; 95% confidence interval [CI], 2.0-2.4; p < 0.001) and 2° of anteversion (range, 0°-11°; 95% CI, 2.0-2.4; p < 0.001). Although at last followup all cups appeared to have stabilized with no radiolucent lines or medial migration, 22% of the cups (94 of 434) had moved more than 3° and so were deemed to be potentially at risk. There were 11 revision procedures (of 429 hips; 2.5%) of which six were for recurrent dislocation, four for femoral fracture, and one for femoral loosening to give an overall all-cause revision rate for all components of 0.25 per 100 component years (95% CI, 0.13-0.43). No revisions were performed for acetabular loosening.The short- to medium-term results of this all-polyethylene monoblock cup demonstrated a low frequency of revision. However, 94 cups were identified as potentially at risk based on movement of > 3° before apparent stabilization. Although those patients seem to be doing well enough now, the current duration of followup may not be sufficient to know that these cups will be durable, because other ongrowth designs have demonstrated a high frequency of late failure after apparent early success.Level IV, therapeutic study.
| S-EPMC4626495 | biostudies-literature
Project description:Background:There are a number of reports of polyethylene liner dissociation of third-generation modular acetabular components. This study compares our experience with 2 contemporary systems to determine whether this is an implant- or class-specific problem. Methods:This is a single-center retrospective study of 961 primary total hip arthroplasties using 2 third-generation modular cementless acetabular shells: Pinnacle (535) and R3 (426) with a polyethylene liner. Details of all revisions were obtained from local databases and the New Zealand Joint Registry. Kaplan-Meier survival curves were calculated for all-cause revision, acetabular reoperation (including liner exchange), and liner dissociation. Results:There were 17 revisions in group 1 (Pinnacle; DePuy Synthes): 17 for recurrent dislocation, 6 for liner dissociations (1.12%), 3 for femoral loosening, and one for deep infection. In group 2 (R3; Smith and Nephew), there were 4 revision procedures: one for infection, 2 for dislocation, and one femoral revision for periprosthetic fracture. There were significantly higher proportions revised in group 1 for all-cause revision, acetabular reoperation, and dissociation (P = .024 to 0.038). The 7-year survival for all-cause revision was 96.1% for Pinnacle and 99.0% for R3 (P = .022), and that in the acetabular reoperation group was 96.9% for Pinnacle and 99.3% for R3 (P = .035). Conclusions:There was a higher revision rate for the Pinnacle acetabular component than for the R3 at 7 years. This was mainly due to polyethylene liner dissociation that can occur early or late. It appears to be a problem specific to the Pinnacle cup design rather than a feature of similar third-generation acetabular components.
| S-EPMC7298534 | biostudies-literature
Project description:BackgroundWe report on the midterm linear and volumetric wear of highly cross-linked polyethylene (HXLPE) and survivorship of 2 prospective young total hip arthroplasty (THA) cohorts that differed by the size of ceramic femoral head used: 28 vs 32 mm.MethodsWe prospectively analyzed 220 consecutive primary THAs in patients aged ≤50 years who received a cementless THA with a ceramic femoral head on HXLPE liner (C-HXLPE). There were 101 patients (46%) with 28-mm heads and 119 patients (54%) who received 32-mm heads at a mean follow-up of 5.5 years (range, 60-109 months). Wear was calculated using Martell Software.ResultsThe 28-mm C-HXLPE cohort demonstrated average linear and volumetric wear of 0.020 mm/y (standard deviation [SD], 0.074; 95% CI, 0.003-0.037) and 18.775 mm(3)/y (SD, 21.743; 95% CI, 13.773-23.778) compared with 0.032 mm/y (SD, 0.087; 95% CI, 0.013-0.050]) and 29.847 mm(3)/y (SD, 35.441; 95% CI, 22.294-37.401) in the 32-mm C-HXLPE group. Subgroup analysis by gender and head size discovered significantly greater wear in females with 32-mm heads compared with 28-mm heads in both linear (0.01, 95% CI = -0.014 to 0.033 vs 0.048, 95% CI = 0.022-0.074 mm/y, P = .004) and volumetric wear (14.11, 95% CI = 8.957-19.271] vs 29.71, 95% CI = 17.584-41.840] mm(3)/y, P = .009). We found a 96% (95% CI = 92.30%-97.94%]) survivorship by Kaplan-Meier analysis at minimum 5 years with no failures because of osteolysis.ConclusionsCeramic on HXLPE demonstrates extremely low wear properties in young patients at midterm follow-up. We identified a gender-dependent difference in wear based on head size, with 32-mm heads being associated with increased wear in females.
| S-EPMC5374861 | biostudies-literature
Project description:BackgroundCross-linked polyethylene (XLPE) liners have shown lower wear rates than conventional polyethylene liners in total hip arthroplasty. The primary aim of our study was to report our most recent analysis of wear rates and clinical outcomes of a third-generation XLPE liner. Secondary aims were to investigate the rate of adverse events related to mechanical failure or oxidation of this liner.MethodsA series of 266 total hip arthroplasties using a specific XLPE liner were retrospectively reviewed. Radiographs were examined to determine linear and volumetric wear rates and presence of osteolysis. Clinical outcomes, revision rates, mechanical failures, and risk factors for accelerated polyethylene wear were additionally investigated.ResultsThe mean age at the time of surgery was 65.8 years and the mean follow-up was 5.5 years. The mean linear wear rate was 0.003 mm/year and the mean volumetric wear rate was 0.42 mm3/year, and there was no evidence of osteolysis. Harris hip scores increased from 50.9 preoperatively to 96.0 at the latest follow-up. The revision rate was 0.4%, with no liner rim fractures and no liner dissociations/loosenings. Femoral head material, head size, age, body mass index, and time since implantation had no effect on wear rates.ConclusionWear rates for this third-generation XLPE liner were low at mid-term follow-up, and no adverse sequelae of oxidation or deleterious mechanical properties were observed. This remained true regardless of femoral head size and material or patient age and body mass index. Further analysis will be necessary to ensure continued wear resistance, oxidative stability, and mechanical strength at long-term follow-up.
| S-EPMC7267711 | biostudies-literature
Project description:The crack procedure is a surgical technique for preparing the implant cavity at revision of loose joint replacement components. It disrupts the neocortical bone shell that typically forms around the cavity. Using an animal model, we compared the crack technique with reaming. Twenty micromotion implants were inserted bilaterally into the knees of 10 dogs according to our revision protocol, allowing formation of a standardized revision cavity (loose implant, fibrous tissue, and sclerotic bone rim). Eight weeks later we performed revision surgery. On the control side, in which the neocortex was removed, the cavity was reamed. On the intervention side, in which the neocortex was perforated but left in situ, the cavity was cracked. For revision we used non-motioning hydroxyapatite (HA)-coated, plasma-sprayed titanium implants. Observation after revision was 4 weeks. The implants revised by the crack technique had better mechanical fixation in all mechanical parameters by the push-out test. The crack revisions also provided more new bone formation around the implants compared with the reamed revisions but had no effect on new bone ongrowth. The data suggest using this bone-sparing technique may be superior to reaming in terms of achieving improved early implant fixation of uncemented HA-coated revision implants.
| S-EPMC2745446 | biostudies-other
Project description:We reviewed 81 consecutive ABG I primary total hip replacements implanted in 72 patients between January 1993 and December 1998. The mean follow-up was 8.2 (range 7-12) years. There was significant polyethylene wear and osteolysis associated with the acetabular cup . The cumulative survival of the cup with revision being the end point at 8.2 years was 95.1% (95% CI: 92-97.6%). However, the cumulative survival of the cup with revision and aseptic loosening together was 72% (95% CI: 61-78%) and survival of the acetabular liner for wear was 62% (95% CI: 48-74%). Stem survival with revision being the end point was 100%. In spite of significant radiological failures of the cups, most patients remained asymptomatic. Though results of the ABG stems in this series were good, we advocate a regular follow-up of all these hips in view of the poor outcome of the cups.
| S-EPMC2254673 | biostudies-other
Project description:Background and purposeIn traditional radiostereometric analysis (RSA), 1 segment defines both the acetabular shell and the polyethylene liner. However, inserting beads into the polyethylene liner permits employment of the shell and liner as 2 separate segments, enabling distinct analysis of the precision of 3 measurement methods in determining femoral head penetration and shell migration.Patients and methodsThe UmRSA program was used to analyze the double examinations of 51 hips to determine if there was a difference in using the shell-only segment, the liner-only segment, or the shell + liner segment to measure wear and acetabular cup stability. The standard deviation multiplied by the critical value (from a t distribution) established the precision of each method.ResultsDue to the imprecision of the automated edge detection, the shell-only method was least desirable. The shell + liner and liner-only methods had a precision of 0.115 mm and 0.086 mm, respectively, when measuring head penetration. For shell migration, the shell + liner had a precision of 0.108 mm, which was better than the precision of the shell-only method. In both the penetration and migration analyses, the shell + liner condition number was statistically significantly lower and the bead count was significantly higher than for the other methods.InterpretationInsertion of beads in the polyethylene improves the precision of femoral head penetration and shell migration measurements. A greater dispersion and number of beads when combining the liner with the shell generated more reliable results in both analyses, by engaging a larger portion of the radiograph.
| S-EPMC4564778 | biostudies-literature