Ontology highlight
ABSTRACT:
SUBMITTER: Veracini L
PROVIDER: S-EPMC2500143 | biostudies-other | 2008 Aug
REPOSITORIES: biostudies-other
Veracini Laurence L Simon Valérie V Richard Véronique V Schraven Burkhart B Horejsi Vaclav V Roche Serge S Benistant Christine C
The Journal of cell biology 20080801 3
Spatial regulation is an important feature of signal specificity elicited by cytoplasmic tyrosine kinases of the Src family (SRC family protein tyrosine kinases [SFK]). Cholesterol-enriched membrane domains, such as caveolae, regulate association of SFK with the platelet-derived growth factor receptor (PDGFR), which is needed for kinase activation and mitogenic signaling. PAG, a ubiquitously expressed member of the transmembrane adaptor protein family, is known to negatively regulate SFK signali ...[more]