Ontology highlight
ABSTRACT:
SUBMITTER: Simmonds P
PROVIDER: S-EPMC250328 | biostudies-other | 1991 Nov
REPOSITORIES: biostudies-other
Simmonds P P Zhang L Q LQ McOmish F F Balfe P P Ludlam C A CA Brown A J AJ
Journal of virology 19911101 11
Sequence change in different hypervariable regions of the external membrane glycoprotein (gp120) of human immunodeficiency virus type 1 (HIV-1) was studied. Viral RNA associated with cell-free virus particles circulating in plasma and proviral DNA present in HIV-infected peripheral blood mononuclear cells (PBMCs) were extracted from blood samples of two currently asymptomatic hemophiliac patients over a 5-year period. HIV sequences were amplified by polymerase chain reaction to allow analysis in ...[more]