Ontology highlight
ABSTRACT:
SUBMITTER: Scherzer CR
PROVIDER: S-EPMC2504800 | biostudies-other | 2008 Aug
REPOSITORIES: biostudies-other
Scherzer Clemens R CR Grass Jeffrey A JA Liao Zhixiang Z Pepivani Imelda I Zheng Bin B Eklund Aron C AC Ney Paul A PA Ng Juliana J McGoldrick Meghan M Mollenhauer Brit B Bresnick Emery H EH Schlossmacher Michael G MG
Proceedings of the National Academy of Sciences of the United States of America 20080731 31
Increased alpha-synuclein gene (SNCA) dosage due to locus multiplication causes autosomal dominant Parkinson's disease (PD). Variation in SNCA expression may be critical in common, genetically complex PD but the underlying regulatory mechanism is unknown. We show that SNCA and the heme metabolism genes ALAS2, FECH, and BLVRB form a block of tightly correlated gene expression in 113 samples of human blood, where SNCA naturally abounds (validated P = 1.6 x 10(-11), 1.8 x 10(-10), and 6.6 x 10(-5)) ...[more]