Ontology highlight
ABSTRACT:
SUBMITTER: Cox CD
PROVIDER: S-EPMC2504843 | biostudies-other | 2008 Aug
REPOSITORIES: biostudies-other
Cox Chris D CD McCollum James M JM Allen Michael S MS Dar Roy D RD Simpson Michael L ML
Proceedings of the National Academy of Sciences of the United States of America 20080731 31
Stochastic fluctuations (or "noise") in the single-cell populations of molecular species are shaped by the structure and biokinetic rates of the underlying gene circuit. The structure of the noise is summarized by its autocorrelation function. In this article, we introduce the noise regulatory vector as a generalized framework for making inferences concerning the structure and biokinetic rates of a gene circuit from its noise autocorrelation function. Although most previous studies have focused ...[more]