Unknown

Dataset Information

0

The O-linked N-acetylglucosamine modification in cellular signalling and the immune system. 'Protein modifications: beyond the usual suspects' review series.


ABSTRACT: The intracellular modification of proteins by the addition of a single O-linked N-acetylglucosamine (O-GlcNAc) molecule is a ubiquitous post-translational modification in eukaryotic cells. It is catalysed by O-linked N-acetylglucosaminyltransferase, which attaches O-GlcNAc to serine/threonine residues, and it is counter-regulated by beta-N-acetylglucosaminidase, which is the antagonistic glycosidase that removes the O-GlcNAc group. O-GlcNAc modification competes with phosphorylation by protein kinases at similar sites, thereby affecting important signalling nodes. Accumulating evidence supports a central role for O-GlcNAc modifications and the corresponding enzymes in the regulation of immune cells, particularly in the activation processes of T and B lymphocytes. Here, we discuss recent advances in the field of O-GlcNAc modifications, focusing on the cells of the immune system.

SUBMITTER: Golks A 

PROVIDER: S-EPMC2515212 | biostudies-other | 2008 Aug

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC2603462 | biostudies-other
| S-EPMC2427391 | biostudies-other
| S-EPMC2572130 | biostudies-other
| S-EPMC2475320 | biostudies-other
| S-EPMC2581850 | biostudies-other
| S-EPMC2529362 | biostudies-other
| S-EPMC3495179 | biostudies-literature
| S-EPMC5473942 | biostudies-literature
| S-EPMC7266299 | biostudies-literature
| S-EPMC7402543 | biostudies-literature