From E-MAPs to module maps: dissecting quantitative genetic interactions using physical interactions.
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ABSTRACT:
SUBMITTER: Ulitsky I
PROVIDER: S-EPMC2516364 | biostudies-other | 2008
REPOSITORIES: biostudies-other
Publications
From E-MAPs to module maps: dissecting quantitative genetic interactions using physical interactions.
Ulitsky Igor I Shlomi Tomer T Kupiec Martin M Shamir Ron R
Molecular systems biology 20080715
Recent technological breakthroughs allow the quantification of hundreds of thousands of genetic interactions (GIs) in Saccharomyces cerevisiae. The interpretation of these data is often difficult, but it can be improved by the joint analysis of GIs along with complementary data types. Here, we describe a novel methodology that integrates genetic and physical interaction data. We use our method to identify a collection of functional modules related to chromosomal biology and to investigate the re ...[more]
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