Ontology highlight
ABSTRACT:
SUBMITTER: Stachelscheid H
PROVIDER: S-EPMC2516889 | biostudies-other | 2008 Aug
REPOSITORIES: biostudies-other
Stachelscheid Heike H Ibrahim Hady H Koch Linda L Schmitz Annika A Tscharntke Michael M Wunderlich F Thomas FT Scott Jeanie J Michels Christian C Wickenhauser Claudia C Haase Ingo I Brüning Jens C JC Niessen Carien M CM
The EMBO journal 20080724 15
The lifelong self-renewal of the epidermis is driven by a progenitor cell population with high proliferative potential. To date, the upstream signals that determine this potential have remained largely elusive. Here, we find that insulin and insulin-like growth factor receptors (IR and IGF-1R) determine epidermal proliferative potential and cooperatively regulate interfollicular epidermal morphogenesis in a cell autonomous manner. Epidermal deletion of either IR or IGF-1R or both in mice progres ...[more]