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Fast comparison of DNA sequences by oligonucleotide profiling.


ABSTRACT: BACKGROUND: The comparison of DNA sequences is a traditional problem in genomics and bioinformatics. Many new opportunities emerge due to the improvement of personal computers, allowing the implementation of novel strategies of analysis. FINDINGS: We describe a new program, called UVWORD, which determines the number of times that each DNA word present in a sequence (target) is found in a second sequence (source), a procedure that we have called oligonucleotide profiling. On a standard computer, the user may search for words of a size ranging from k = 1 to k = 14 nucleotides. Average counts for groups of contiguous words may also be established. The rate of analysis on standard computers is from 3.4 (k = 14) to 16 millions of words per second (1

SUBMITTER: Arnau V 

PROVIDER: S-EPMC2518268 | biostudies-other | 2008

REPOSITORIES: biostudies-other

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Fast comparison of DNA sequences by oligonucleotide profiling.

Arnau Vicente V   Gallach Miguel M   Marín Ignacio I  

BMC research notes 20080228


<h4>Background</h4>The comparison of DNA sequences is a traditional problem in genomics and bioinformatics. Many new opportunities emerge due to the improvement of personal computers, allowing the implementation of novel strategies of analysis.<h4>Findings</h4>We describe a new program, called UVWORD, which determines the number of times that each DNA word present in a sequence (target) is found in a second sequence (source), a procedure that we have called oligonucleotide profiling. On a standa  ...[more]

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