Ontology highlight
ABSTRACT:
SUBMITTER: Stielow B
PROVIDER: S-EPMC2529347 | biostudies-other | 2008 Sep
REPOSITORIES: biostudies-other
Stielow Bastian B Sapetschnig Alexandra A Wink Christina C Krüger Imme I Suske Guntram G
EMBO reports 20080711 9
Modification of many transcription factors including Sp3 and steroidogenic factor 1 with the small ubiquitin-like modifier (SUMO) is associated with transcriptional repression. Here, we show that SUMOylation of transcription factors bound to DNA provokes the establishment of compacted repressive chromatin with characteristics of heterochromatin. Chromatin immunoprecipitation experiments revealed SUMO-dependent recruitment of the chromatin remodeller Mi-2, MBT-domain proteins, heterochromatic pro ...[more]