Ontology highlight
ABSTRACT:
SUBMITTER: Hajishengallis G
PROVIDER: S-EPMC2533224 | biostudies-other | 2008 Sep
REPOSITORIES: biostudies-other
Proceedings of the National Academy of Sciences of the United States of America 20080902 36
We report a mechanism of microbial evasion of Toll-like receptor (TLR)-mediated immunity that depends on CXCR4 exploitation. Specifically, the oral/systemic pathogen Porphyromonas gingivalis induces cross-talk between CXCR4 and TLR2 in human monocytes or mouse macrophages and undermines host defense. This is accomplished through its surface fimbriae, which induce CXCR4/TLR2 co-association in lipid rafts and interact with both receptors: Binding to CXCR4 induces cAMP-dependent protein kinase A (P ...[more]