Ontology highlight
ABSTRACT:
SUBMITTER: Leconte AM
PROVIDER: S-EPMC2536686 | biostudies-other | 2006 May
REPOSITORIES: biostudies-other
Leconte Aaron M AM Matsuda Shigeo S Romesberg Floyd E FE
Journal of the American Chemical Society 20060501 21
A third DNA base pair, which is synthesized efficiently and selectively, would have wide ranging applications from synthetic organisms to nucleic acids biotechnology. Hydrophobic unnatural nucleobases offer a promising route to such a pair, but are often limited by inefficient extension, defined as synthesis immediately following the unnatural pair. Here, we describe a simple screen which enables the characterization of large numbers of previously uncharacterized hetero base pairs. From this scr ...[more]