The effect of Gaussian noise on the threshold, dynamic range, and loudness of analogue cochlear implant stimuli.
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ABSTRACT:
SUBMITTER: Morse RP
PROVIDER: S-EPMC2538414 | biostudies-other | 2007 Mar
REPOSITORIES: biostudies-other
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Project description:The multichannel design of contemporary cochlear implants (CIs) is predicated on the assumption that each channel activates a relatively restricted and independent sector of the deaf auditory nerve array, just as a sound within a restricted frequency band activates a restricted region of the normal cochlea The independence of CI channels, however, is limited; and the factors that determine their independence, the relative overlap of the activity patterns that they evoke, are poorly understood. In this study, we evaluate the spread of activity evoked by cochlear implant channels by monitoring activity at 16 sites along the tonotopic axis of the guinea pig inferior colliculus (IC). "Spatial tuning curves" (STCs) measured in this way serve as an estimate of activation spread within the cochlea and the ascending auditory pathways. We contrast natural stimulation using acoustic tones with two kinds of electrical stimulation either (1) a loose fitting banded array consisting of a cylindrical silicone elastomer carrier with a linear series of ring contacts; or (2) a space-filling array consisting of a tapered silicone elastomer carrier that is designed to fit snugly into the guinea pig scala tympani with a linear series of ball contacts positioned along it Spatial tuning curves evoked by individual acoustic tones, and by activation of each contact of each array as a monopole, bipole or tripole were recorded. Several channel configurations and a wide range of electrode separations were tested for each array, and their thresholds and selectivity were estimated. The results indicate that the tapered space-filling arrays evoked more restricted activity patterns at lower thresholds than did the banded arrays. Monopolar stimulation (one intracochlear contact activated with an extracochlear return) using either array evoked broad activation patterns that involved the entire recording array at current levels <6dBSL, but at relatively low thresholds. Bi- and tri-polar configurations of both array types evoked more restricted activity patterns, but their thresholds were higher than those of monopolar configurations. Bipolar and tripolar configurations with closely spaced contacts evoked activity patterns that were comparable to those evoked by pure tones. As the spacing of bipolar electrodes was increased (separations >1mm), the activity patterns became broader and evoked patterns with two distinct threshold minima, one associated with each contact.
| S-EPMC2387102 | biostudies-literature
Project description:OBJECTIVES:The standard, monopolar (MP) electrode configuration used in commercially available cochlear implants (CI) creates a broad electrical field, which can lead to unwanted channel interactions. Use of more focused configurations, such as tripolar and phased array, has led to mixed results for improving speech understanding. The purpose of the present study was to assess the efficacy of a physiologically inspired configuration called dynamic focusing, using focused tripolar stimulation at low levels and less focused stimulation at high levels. Dynamic focusing may better mimic cochlear excitation patterns in normal acoustic hearing, while reducing the current levels necessary to achieve sufficient loudness at high levels. DESIGN:Twenty postlingually deafened adult CI users participated in the study. Speech perception was assessed in quiet and in a four-talker babble background noise. Speech stimuli were closed-set spondees in noise, and medial vowels at 50 and 60 dB SPL in quiet and in noise. The signal to noise ratio was adjusted individually such that performance was between 40 and 60% correct with the MP strategy. Subjects were fitted with three experimental strategies matched for pulse duration, pulse rate, filter settings, and loudness on a channel-by-channel basis. The strategies included 14 channels programmed in MP, fixed partial tripolar (? = 0.8), and dynamic partial tripolar (? at 0.8 at threshold and 0.5 at the most comfortable level). Fifteen minutes of listening experience was provided with each strategy before testing. Sound quality ratings were also obtained. RESULTS:Speech perception performance for vowel identification in quiet at 50 and 60 dB SPL and for spondees in noise was similar for the three tested strategies. However, performance on vowel identification in noise was significantly better for listeners using the dynamic focusing strategy. Sound quality ratings were similar for the three strategies. Some subjects obtained more benefit than others, with some individual differences explained by the relation between loudness growth and the rate of change from focused to broader stimulation. CONCLUSIONS:These initial results suggest that further exploration of dynamic focusing is warranted. Specifically, optimizing such strategies on an individual basis may lead to improvements in speech perception for more adult listeners and improve how CIs are tailored. Some listeners may also need a longer period of time to acclimate to a new program.
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Project description:Chromatin influences gene expression by restricting access of DNA binding proteins to their cognate sites in the genome. Large-scale characterization of nucleosome positioning in Saccharomyces cerevisiae has revealed a stereotyped promoter organization in which a nucleosome-free region (NFR) is present within several hundred base pairs upstream of the translation start site. Many transcription factors bind within NFRs and nucleate chromatin remodelling events which then expose other cis-regulatory elements. However, it is not clear how transcription-factor binding and chromatin influence quantitative attributes of gene expression. Here we show that nucleosomes function largely to decouple the threshold of induction from dynamic range. With a series of variants of one promoter, we establish that the affinity of exposed binding sites is a primary determinant of the level of physiological stimulus necessary for substantial gene activation, and sites located within nucleosomal regions serve to scale expression once chromatin is remodelled. Furthermore, we find that the S. cerevisiae phosphate response (PHO) pathway exploits these promoter designs to tailor gene expression to different environmental phosphate levels. Our results suggest that the interplay of chromatin and binding-site affinity provides a mechanism for fine-tuning responses to the same cellular state. Moreover, these findings may be a starting point for more detailed models of eukaryotic transcriptional control.
| S-EPMC2435410 | biostudies-literature
Project description:ObjectivesPrevious studies investigating speech perception in noise have typically been conducted with static masker positions. The aim of this study was to investigate the effect of spatial separation of source and masker (spatial release from masking, SRM) in a moving masker setup and to evaluate the impact of adaptive beamforming in comparison with fixed directional microphones in cochlear implant (CI) users.DesignSpeech reception thresholds (SRT) were measured in S0N0 and in a moving masker setup (S0Nmove) in 12 normal hearing participants and 14 CI users (7 subjects bilateral, 7 bimodal with a hearing aid in the contralateral ear). Speech processor settings were a moderately directional microphone, a fixed beamformer, or an adaptive beamformer. The moving noise source was generated by means of wave field synthesis and was smoothly moved in a shape of a half-circle from one ear to the contralateral ear. Noise was presented in either of two conditions: continuous or modulated.ResultsSRTs in the S0Nmove setup were significantly improved compared to the S0N0 setup for both the normal hearing control group and the bilateral group in continuous noise, and for the control group in modulated noise. There was no effect of subject group. A significant effect of directional sensitivity was found in the S0Nmove setup. In the bilateral group, the adaptive beamformer achieved lower SRTs than the fixed beamformer setting. Adaptive beamforming improved SRT in both CI user groups substantially by about 3 dB (bimodal group) and 8 dB (bilateral group) depending on masker type.ConclusionsCI users showed SRM that was comparable to normal hearing subjects. In listening situations of everyday life with spatial separation of source and masker, directional microphones significantly improved speech perception with individual improvements of up to 15 dB SNR. Users of bilateral speech processors with both directional microphones obtained the highest benefit.
| S-EPMC4430230 | biostudies-literature
Project description:This study compared spatial speech-in-noise performance in two cochlear implant (CI) patient groups: bimodal listeners, who use a hearing aid contralaterally to support their impaired acoustic hearing, and listeners with contralateral normal hearing, i.e., who were single-sided deaf before implantation. Using a laboratory setting that controls for head movements and that simulates spatial acoustic scenes, speech reception thresholds were measured for frontal speech-in-stationary noise from the front, the left, or the right side. Spatial release from masking (SRM) was then extracted from speech reception thresholds for monaural and binaural listening. SRM was found to be significantly lower in bimodal CI than in CI single-sided deaf listeners. Within each listener group, the SRM extracted from monaural listening did not differ from the SRM extracted from binaural listening. In contrast, a normal-hearing control group showed a significant improvement in SRM when using two ears in comparison to one. Neither CI group showed a binaural summation effect; that is, their performance was not improved by using two devices instead of the best monaural device in each spatial scenario. The results confirm a "listening with the better ear" strategy in the two CI patient groups, where patients benefited from using two ears/devices instead of one by selectively attending to the better one. Which one is the better ear, however, depends on the spatial scenario and on the individual configuration of hearing loss.
| S-EPMC6669847 | biostudies-literature
Project description:It has been known that short-time auditory stimulation can contribute to the improvement of the balancing ability of the human body. The present study aims to explore the effects of white Gaussian noise (WGN) of different intensities and frequencies on dynamic balance performance in healthy young adults. A total of 20 healthy young participants were asked to stand at a dynamic balance force platform, which swung along the x-axis with an amplitude of?±?4° and frequency of 1 Hz. Their center of pressure (COP) trajectories were recorded when they were stimulated by WGN of different intensities (block 1) and different frequencies (block 2). A traditional method and detrended fluctuation analysis (DFA) were used for data preprocessing. The authors found that only with 75–85 dB WGN, the COP parameters improved. WGN frequency did not affect the dynamic balance performance of all the participants. The DFA results indicated stimulation with 75 dB WGN enhanced the short-term index and reduced the crossover point. Stimulation with 500 Hz and 2500 Hz WGN significantly enhanced the short-term index. These results suggest that 75 dB WGN and 500 Hz and 2500 Hz WGN improved the participants’ dynamic balance performance. The results of this study indicate that a certain intensity of WGN is indispensable to achieve a remarkable improvement in dynamic balance. The DFA results suggest that WGN only affected the short-term persistence, indicating the potential of WGN being considered as an adjuvant therapy in low-speed rehabilitation training.
| S-EPMC7943824 | biostudies-literature
Project description:Reverberation is especially detrimental for cochlear implant listeners; thus, mitigating its effects has the potential to provide significant improvements to cochlear implant communication. Efforts to model and correct for reverberation in acoustic listening scenarios can be quite complex, requiring estimation of the room transfer function and localization of the source and receiver. However, due to the limited resolution associated with cochlear implant stimulation, simpler processing for reverberation detection and mitigation may be possible for cochlear implants. This study models speech stimuli in a cochlear implant on a per-channel basis both in quiet and in reverberation, and assesses the efficacy of these models for detecting the presence of reverberation. This study was able to successfully detect reverberation in cochlear implant pulse trains, and the results appear to be robust to varying room conditions and cochlear implant stimulation parameters. Reverberant signals were detected 100% of the time for a long reverberation time of 1.2 s and 86% of the time for a shorter reverberation time of 0.5 s.
| S-EPMC3745505 | biostudies-other
Project description:To evaluate monaural beamforming in bimodally aided cochlear implant (CI) users.The study enrolled twelve adult bimodal listeners with at least six months of CI-experience and using a contralateral hearing aid (HA) most of the daytime. Participants were uniformly fitted with the same CI speech processor and HA, giving access to an identical monaural beamformer in both ears. A within-subject repeated measures design evaluated three directional configurations [omnidirectional, asymmetric directivity (in CI alone) and symmetric directivity (in both CI and HA)] in two noise types [stationary and fluctuating]. Bimodal speech reception thresholds (SRT) as well as listening effort ratings were assessed in a diffuse noise field.Symmetric monaural beamforming provided a significant SRT improvement of 2.6 dB SNR, compared to 1.6 dB SNR for asymmetric monaural beamforming. Directional benefits were similarly observed in stationary and fluctuating noise. Directivity did not contribute to less listening effort in addition to improvement in speech intelligibility. Bimodal performance was about 7 dB SNR worse in fluctuating than in stationary noise.Monaural beamforming provided substantial benefit for speech intelligibility in noise for bimodal listeners. The greatest benefit occurred when monaural beamforming was activated symmetrically in both CI and HA. Monaural beamforming does not bridge the gap between bimodal and normal hearing performance, especially in fluctuating noise. Results advocate further bimodal co-operation.This trial was registered in www.trialregister.nl under number NTR4901.
| S-EPMC4990192 | biostudies-literature
Project description:Speech understanding in noisy environments is still one of the major challenges for cochlear implant (CI) users in everyday life. We evaluated a speech enhancement algorithm based on neural networks (NNSE) for improving speech intelligibility in noise for CI users. The algorithm decomposes the noisy speech signal into time-frequency units, extracts a set of auditory-inspired features and feeds them to the neural network to produce an estimation of which frequency channels contain more perceptually important information (higher signal-to-noise ratio, SNR). This estimate is used to attenuate noise-dominated and retain speech-dominated CI channels for electrical stimulation, as in traditional n-of-m CI coding strategies. The proposed algorithm was evaluated by measuring the speech-in-noise performance of 14 CI users using three types of background noise. Two NNSE algorithms were compared: a speaker-dependent algorithm, that was trained on the target speaker used for testing, and a speaker-independent algorithm, that was trained on different speakers. Significant improvements in the intelligibility of speech in stationary and fluctuating noises were found relative to the unprocessed condition for the speaker-dependent algorithm in all noise types and for the speaker-independent algorithm in 2 out of 3 noise types. The NNSE algorithms used noise-specific neural networks that generalized to novel segments of the same noise type and worked over a range of SNRs. The proposed algorithm has the potential to improve the intelligibility of speech in noise for CI users while meeting the requirements of low computational complexity and processing delay for application in CI devices.
| S-EPMC5256482 | biostudies-literature
Project description:Many cochlear implant (CI) users achieve excellent speech understanding in acoustically quiet conditions but most perform poorly in the presence of background noise. An important contributor to this poor speech-in-noise performance is the limited transmission of low-frequency sound information through CIs. Recent work has suggested that tactile presentation of this low-frequency sound information could be used to improve speech-in-noise performance for CI users. Building on this work, we investigated whether vibro-tactile stimulation can improve speech intelligibility in multi-talker noise. The signal used for tactile stimulation was derived from the speech-in-noise using a computationally inexpensive algorithm. Eight normal-hearing participants listened to CI simulated speech-in-noise both with and without concurrent tactile stimulation of their fingertip. Participants' speech recognition performance was assessed before and after a training regime, which took place over 3 consecutive days and totaled around 30?min of exposure to CI-simulated speech-in-noise with concurrent tactile stimulation. Tactile stimulation was found to improve the intelligibility of speech in multi-talker noise, and this improvement was found to increase in size after training. Presentation of such tactile stimulation could be achieved by a compact, portable device and offer an inexpensive and noninvasive means for improving speech-in-noise performance in CI users.
| S-EPMC6144588 | biostudies-literature