Emergent decision-making in biological signal transduction networks.
Ontology highlight
ABSTRACT:
SUBMITTER: Helikar T
PROVIDER: S-EPMC2538858 | biostudies-other | 2008 Feb
REPOSITORIES: biostudies-other
Publications
Emergent decision-making in biological signal transduction networks.
Helikar Tomás T Konvalina John J Heidel Jack J Rogers Jim A JA
Proceedings of the National Academy of Sciences of the United States of America 20080204 6
The complexity of biochemical intracellular signal transduction networks has led to speculation that the high degree of interconnectivity that exists in these networks transforms them into an information processing network. To test this hypothesis directly, a large scale model was created with the logical mechanism of each node described completely to allow simulation and dynamical analysis. Exposing the network to tens of thousands of random combinations of inputs and analyzing the combined dyn ...[more]
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