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Role of macrophage inflammatory protein-1alpha in T-cell-mediated immunity to viral infection.


ABSTRACT: The immune response to lymphocytic choriomeningitis virus in mice lacking macrophage inflammatory protein-1alpha (MIP-1alpha) was evaluated. Generation of virus-specific effector T cells is unimpaired in MIP-1alpha-deficient mice. Furthermore, MIP-1alpha is not required for T-cell-mediated virus control or virus-induced T-cell-dependent inflammation. Thus, MIP-1alpha is not mandatory for T-cell-mediated antiviral immunity.

SUBMITTER: Madsen AN 

PROVIDER: S-EPMC254281 | biostudies-other | 2003 Nov

REPOSITORIES: biostudies-other

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