Ontology highlight
ABSTRACT:
SUBMITTER: Li H
PROVIDER: S-EPMC2542873 | biostudies-other | 2008 Feb
REPOSITORIES: biostudies-other
Li Hongmei H Chen Yingbei Y Jones Adrienne F AF Sanger Richard H RH Collis Leon P LP Flannery Richard R McNay Ewan C EC Yu Tingxi T Schwarzenbacher Robert R Bossy Blaise B Bossy-Wetzel Ella E Bennett Michael V L MV Pypaert Marc M Hickman John A JA Smith Peter J S PJ Hardwick J Marie JM Jonas Elizabeth A EA
Proceedings of the National Academy of Sciences of the United States of America 20080204 6
Maturation of neuronal synapses is thought to involve mitochondria. Bcl-xL protein inhibits mitochondria-mediated apoptosis but may have other functions in healthy adult neurons in which Bcl-xL is abundant. Here, we report that overexpression of Bcl-xL postsynaptically increases frequency and amplitude of spontaneous miniature synaptic currents in rat hippocampal neurons in culture. Bcl-xL, overexpressed either pre or postsynaptically, increases synapse number, the number and size of synaptic ve ...[more]