Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

CCN3: Doctor Jekyll and Mister Hyde.

ABSTRACT: CCN proteins are key regulators of signaling pathways that are essential for the control of normal life, from birth to death. As such, they make use of their unique mosaic structure to interact with several other regulatory proteins and ligands that control the fate of living cells. The various functions attributed to the CCN proteins may sometimes appear contradictory, but this situation reflects the complexity of the multimolecular scaffolds in which CCN proteins are engaged and the critical impact of the microenvironment that dictates the bioavailability of the elementary building blocks. CCN3 is one of the best examples of a CCN protein showing biological properties which may at first glance appear opposite or contradictory. Indeed, CCN3 acts both as a tumor suppressor and is associated with higher metastatic potential. Furthermore, the physical interaction of CCN3 with VEGF and its potential antiangionenic activity in glioma cells are in apparent contradiction with its proangiogenic activity in rabbit cornea. In this communication, I am revisiting the observations that led us to these apparent contradictions. After pointing out how the methodologies that were employed might have contributed to the confusion, I briefly discuss the dual biological activities of CCN3 in the context of tumor cell engineering and survival prognosis.

SUBMITTER: Perbal B

PROVIDER: S-EPMC2570013 | biostudies-other | 2008 Jun

REPOSITORIES: biostudies-other

ACCESS DATA

Json Xml

Similar Datasets

4-Diethyl-amino-3,5-diisopropyl-benzalde-hyde.

Project description:The title benzaldehyde, C(17)H(27)NO, was prepared via lithia-tion of bromoaniline and reaction with DMF. In the crystal, the molecule adopts a C2-symmetrical conformation; nevertheless, two modes of disorder are present: the orientation of the aldehyde group (occupancy ratio 0.5:0.5) and of symmetry-equivalent ethyl groups [occupancy ratio 0.595 (7):0.405 (7)]. The phenyl-ene ring and the carbonyl group are essentially coplanar [C-C-C-O torsion angle = -179.0 (4)°] but the dihedral angle between the mean planes of the phenyl-ene ring and the amino group = 67.5 (2)°. This and the long [1.414 (3) Å] aniline C-N bond indicate electronic decoupling between the carbonyl and amino groups. The angle sum of 359.9 (2)° around the N atom results from steric compression-induced rehybridization.

| S-EPMC3238983 | biostudies-literature

2,2'-[Ethane-1,2-diylbis(-oxy)]dibenz-alde-hyde.

Project description:In the title compound, C16H14O4, the benzene rings are inclined at a dihedral angle of 75.14?(9)°. The torsion angle of the bridging O-C-C-O group is -76.50?(11)°. In the crystal, mol-ecules are linked by C-H?O hydrogen bonds, forming C(6) chains along [100]. Furthermore, C-H?? inter-actions and ?-? stacking inter-actions [centroid-centroid distances = 3.6957?(7) and 3.6735?(8)?Å] contribute to the stability of the crystal packing.

| S-EPMC3793757 | biostudies-literature

2,2'-Diisopropoxy-5,5'-methyl-enedi-benz-alde-hyde.

Project description:Mol-ecules of the title compound, C(21)H(24)O(4), are located on a twofold rotation axis running through the central methyl-ene C atom. The aldehyde group is coplanar with the benzene ring [C-C-C-O = 175.7 (4) °].

| S-EPMC3393997 | biostudies-literature

The Jekyll-and-Hyde chemistry of Phaeobacter gallaeciensis.

Project description:Emiliania huxleyi, an environmentally important marine microalga, has a bloom-and-bust lifestyle in which massive algal blooms appear and fade. Phaeobacter gallaeciensis belongs to the roseobacter clade of α-Proteobacteria, the populations of which wax and wane with that of E. huxleyi. Roseobacter are thought to promote algal growth by biosynthesizing and secreting antibiotics and growth stimulants (auxins). Here we show that P. gallaeciensis switches its secreted small molecule metabolism to the production of potent and selective algaecides, the roseobacticides, in response to p-coumaric acid, an algal lignin breakdown product that is symptomatic of aging algae. This switch converts P. gallaeciensis into an opportunistic pathogen of its algal host.

| S-EPMC3376411 | biostudies-literature

Jekyll and Hyde: Activating the Hypoxic Translational Machinery.

Project description:Global translational remodeling has emerged as a principal mechanism of biological adaptation. Oxygen deficiency (hypoxia) disables the basal protein synthesis machinery ('Jekyll') and activates a hypoxic translational architecture ('Hyde') to drive translatome remodeling. Independent from mRNA-level fluctuations, this newer paradigm modernizes a field traditionally dominated by the hypoxia-inducible factor (HIF) transcriptional program.

| S-EPMC8720417 | biostudies-literature

Prostate stem cell antigen: a Jekyll and Hyde molecule?

Project description:Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol (GPI)-anchored cell surface protein. Although PSCA is thought to be involved in intracellular signaling, much remains unknown about its physiological function and regulatory mechanism in normal and cancer cells. It is up-regulated in several major cancers including prostate, bladder, and pancreatic cancers. The expression of PSCA is positively correlated with advanced clinical stage and metastasis in prostate cancers and is also associated with malignant progression of premalignant prostate lesions. Therefore, PSCA has been proposed as a biomarker of diagnosis and prognosis, as well as a target of therapy for these cancers. In addition, PSCA has also shown clinical potential in immunotherapy as a prostate-specific antigen, which, when presented by dendritic cells, may elicit strong tumor-specific immunity. In contrast, PSCA is down-regulated in esophageal and gastric cancer and may have a tumor-suppressing function in the gastric epithelium. Recent exciting findings that genetic variations of PSCA conferred increased risks of gastric cancer and bladder cancer have opened up a new avenue of research about the pathological function of PSCA. PSCA seems to be a Jekyll and Hyde molecule that plays differential roles, tumor promoting or suppressing, depending on the cellular context.

| S-EPMC2905486 | biostudies-literature

HyDe: A Python Package for Genome-Scale Hybridization Detection.

Project description:The analysis of hybridization and gene flow among closely related taxa is a common goal for researchers studying speciation and phylogeography. Many methods for hybridization detection use simple site pattern frequencies from observed genomic data and compare them to null models that predict an absence of gene flow. The theory underlying the detection of hybridization using these site pattern probabilities exploits the relationship between the coalescent process for gene trees within population trees and the process of mutation along the branches of the gene trees. For certain models, site patterns are predicted to occur in equal frequency (i.e., their difference is 0), producing a set of functions called phylogenetic invariants. In this article, we introduce HyDe, a software package for detecting hybridization using phylogenetic invariants arising under the coalescent model with hybridization. HyDe is written in Python and can be used interactively or through the command line using pre-packaged scripts. We demonstrate the use of HyDe on simulated data, as well as on two empirical data sets from the literature. We focus in particular on identifying individual hybrids within population samples and on distinguishing between hybrid speciation and gene flow. HyDe is freely available as an open source Python package under the GNU GPL v3 on both GitHub (https://github.com/pblischak/HyDe) and the Python Package Index (PyPI: https://pypi.python.org/pypi/phyde).

| S-EPMC6454532 | biostudies-literature

6-Fluoro-4-oxo-4H-chromene-3-carbalde-hyde.

Project description:In the title compound, C10H5FO3, the non-H atoms are essentially coplanar (r.m.s. deviation = 0.0071?Å), with the largest deviation from the mean plane [0.0203?(15)?Å] being found for the ring C atom in the 2-position. In the crystal, mol-ecules are linked into a three-dimensional architecture via C-H?O hydrogen bonds and ?-? stacking inter-actions between the chromone units along the a-axis direction [centroid-centroid distance between the benzene and pyran rings = 3.707?(2)?Å].

| S-EPMC4011281 | biostudies-literature

4,6-Di-tert-butyl-2,3-di-hydroxy-benzalde-hyde.

Project description:The title compound, C15H22O3, crystallizes with two independent mol-ecules in the asymmetric unit. In each mol-ecule, one hy-droxy group (at position 2) is involved in an intra-molecular O-H?O hydrogen bond, and another one (at position 3) exhibits bifurcated hydrogen-bonding being involved in intra- and inter-molecular O-H?O inter-actions. In the crystal, O-H?O hydrogen bonds link alternating independent mol-ecules into chains running along [010].

| S-EPMC3790425 | biostudies-literature

8-Fluoro-4-oxo-4H-chromene-3-carbalde-hyde.

Project description:In the title compound, C10H5FO3, the non-H atoms of the 8-fluoro-chromone unit are essentially coplanar (r.m.s. deviation = 0.0259?Å), with a largest deviation from the mean plane of 0.0660?(12)?Å for the chromone carbonyl O atom. The formyl group is twisted with respect to the attached ring [C-C-C-O torsion angles = -11.00?(19) and 170.81?(11)°]. In the crystal, mol-ecules are linked via weak C-H?O hydrogen bonds along the a axis and [-101], forming corrugated layers parallel to (010). In addition, ?-? stacking inter-actions [centroid-centroid distance between the planes of the pyran and benzene rings = 3.519?(2)?Å] are observed between these layers.

| S-EPMC4120633 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data