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An improved system for the palladium-catalyzed borylation of aryl halides with pinacol borane.

ABSTRACT: A highly efficient method for the palladium-catalyzed borylation of aryl halides with an inexpensive and atom-economical boron source, pinacol borane, has been developed. This system allows for the conversion of aryl and heteroaryl iodides, bromides, and several chlorides, containing a variety of functional groups, to the corresponding pinacol boronate esters. In addition to the increase in substrate scope, this is the first general method where relatively low quantities of catalyst and short reaction times can be employed.

SUBMITTER: Billingsley KL

PROVIDER: S-EPMC2574621 | biostudies-other | 2008 Jul

REPOSITORIES: biostudies-other

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An improved system for the palladium-catalyzed borylation of aryl halides with pinacol borane.

Billingsley Kelvin L KL Buchwald Stephen L SL

The Journal of organic chemistry 20080625 14

A highly efficient method for the palladium-catalyzed borylation of aryl halides with an inexpensive and atom-economical boron source, pinacol borane, has been developed. This system allows for the conversion of aryl and heteroaryl iodides, bromides, and several chlorides, containing a variety of functional groups, to the corresponding pinacol boronate esters. In addition to the increase in substrate scope, this is the first general method where relatively low quantities of catalyst and short re ...[more]

PMID: 18576604

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