Ontology highlight
ABSTRACT:
SUBMITTER: Kolber BJ
PROVIDER: S-EPMC2575312 | biostudies-other | 2008 Aug
REPOSITORIES: biostudies-other
Kolber Benedict J BJ Roberts Marie S MS Howell Maureen P MP Wozniak David F DF Sands Mark S MS Muglia Louis J LJ
Proceedings of the National Academy of Sciences of the United States of America 20080811 33
The amygdala is a key limbic area involved in fear responses and pavlovian conditioning with the potential to directly respond to endocrine signals associated with fear or stress. To gain insights into the molecular mechanisms and subregional specificity of fear conditioning, we disrupted type II glucocorticoid receptors (GRs) in the central nucleus of the amygdala (CeA) by delivering lentiviral vectors containing Cre-recombinase into floxed-GR mice. GR deletion in the CeA (CeAGRKO mice) prevent ...[more]