Ontology highlight
ABSTRACT:
SUBMITTER: Muller AJ
PROVIDER: S-EPMC2579380 | biostudies-other | 2008 Nov
REPOSITORIES: biostudies-other
Muller Alexander J AJ Sharma Madhav D MD Chandler Phillip R PR Duhadaway James B JB Everhart Mary E ME Johnson Burles A BA Kahler David J DJ Pihkala Jeanene J Soler Alejandro Peralta AP Munn David H DH Prendergast George C GC Mellor Andrew L AL
Proceedings of the National Academy of Sciences of the United States of America 20081024 44
Topical application of phorbol myristate acetate (PMA) elicits intense local inflammation that facilitates outgrowth of premalignant lesions in skin after carcinogen exposure. The inflammatory response to PMA treatment activates immune stimulatory mechanisms. However, we show here that PMA exposure also induces plasmacytoid dendritic cells (pDCs) in local draining lymph nodes (dLNs) to express indoleamine 2,3 dioxygenase (IDO), which confers T cell suppressor activity on pDCs. The induced IDO-me ...[more]