Ontology highlight
ABSTRACT:
SUBMITTER: Monaco A
PROVIDER: S-EPMC2583995 | biostudies-other | 2008
REPOSITORIES: biostudies-other
Journal of translational medicine 20081030
The need for fast, efficient, and less costly means to screen genetic variants associated with disease predisposition led us to develop an oligo-nucleotide array-based process for gene-specific single nucleotide polymorphism (SNP) genotyping. This cost-effective, high-throughput strategy has high sensitivity and the same degree of accuracy as direct sequencing, the current gold standard for genetic screening. We used the BRCA1 breast and ovarian cancer predisposing gene model for the validation ...[more]