Ontology highlight
ABSTRACT:
SUBMITTER: Ishimaru N
PROVIDER: S-EPMC2585852 | biostudies-other | 2008 Nov
REPOSITORIES: biostudies-other
Ishimaru Naozumi N Arakaki Rieko R Yoshida Satoko S Yamada Akiko A Noji Sumihare S Hayashi Yoshio Y
The Journal of experimental medicine 20081117 12
Although several autoimmune diseases are known to develop in postmenopausal women, the mechanisms by which estrogen deficiency influences autoimmunity remain unclear. Recently, we found that retinoblastoma-associated protein 48 (RbAp48) induces tissue-specific apoptosis in the exocrine glands depending on the level of estrogen deficiency. In this study, we report that transgenic (Tg) expression of RbAp48 resulted in the development of autoimmune exocrinopathy resembling Sjögren's syndrome. CD4(+ ...[more]