Ontology highlight
ABSTRACT:
SUBMITTER: Zeng W
PROVIDER: S-EPMC2586614 | biostudies-other | 2008 Nov
REPOSITORIES: biostudies-other
Molecular cell 20081101 3
The receptor-evoked Ca(2+) signal includes activation of the store-operated channels (SOCs) TRPCs and the Orais. Although both are gated by STIM1, it is not known how STIM1 gates the channels and whether STIM1 gates the TRPCs and Orais by the same mechanism. Here, we report the molecular mechanism by which STIM1 gates TRPC1, which involves interaction between two conserved, negatively charged aspartates in TRPC1((639)DD(640)) with the positively charged STIM1((684)KK(685)) in STIM1 polybasic dom ...[more]