Ontology highlight
ABSTRACT:
SUBMITTER: Chou WC
PROVIDER: S-EPMC2599873 | biostudies-other | 2008 Dec
REPOSITORIES: biostudies-other
Chou Wen-Cheng WC Wang Hui-Chun HC Wong Fen-Hwa FH Ding Shian-ling SL Wu Pei-Ei PE Shieh Sheau-Yann SY Shen Chen-Yang CY
The EMBO journal 20081030 23
The DNA damage response (DDR) has an essential function in maintaining genomic stability. Ataxia telangiectasia-mutated (ATM)-checkpoint kinase 2 (Chk2) and ATM- and Rad3-related (ATR)-Chk1, triggered, respectively, by DNA double-strand breaks and blocked replication forks, are two major DDRs processing structurally complicated DNA damage. In contrast, damage repaired by base excision repair (BER) is structurally simple, but whether, and how, the DDR is involved in repairing this damage is uncle ...[more]