Ontology highlight
ABSTRACT:
SUBMITTER: Wang X
PROVIDER: S-EPMC2615084 | biostudies-other | 2009 Jan
REPOSITORIES: biostudies-other
Wang Xin X Rao Raghavendra Pralhada RP Kosakowska-Cholody Teresa T Masood M Athar MA Southon Eileen E Zhang Helin H Berthet Cyril C Nagashim Kunio K Veenstra Timothy K TK Tessarollo Lino L Acharya Usha U Acharya Jairaj K JK
The Journal of cell biology 20090101 1
Ceramide transfer protein (CERT) functions in the transfer of ceramide from the endoplasmic reticulum (ER) to the Golgi. In this study, we show that CERT is an essential gene for mouse development and embryonic survival and, quite strikingly, is critical for mitochondrial integrity. CERT mutant embryos accumulate ceramide in the ER but also mislocalize ceramide to the mitochondria, compromising their function. Cells in mutant embryos show abnormal dilation of the ER and degenerating mitochondria ...[more]