Unknown

Dataset Information

0

Bystander killing during avian leukosis virus subgroup B infection requires TVB(S3) signaling.


ABSTRACT: Cell killing by avian leukosis virus subgroup B (ALV-B) in cultures has been extensively studied, but the molecular basis of this process has not been established. Here we show that superinfection, which has been linked to cell killing by ALV-B, plays no crucial role in cell death induction. Instead, we show that signaling by the ALV-B receptor, TVB(S3), a member of the tumor necrosis factor receptor family, is essential for ALV-B-mediated cell death. TVB(S3) activated caspase-dependent apoptosis during ALV-B infection. Strikingly, apoptosis induction occurred predominantly in uninfected cells, while ALV-B-infected cells were protected against cell death. This bystander killing phenomenon was reproduced in a virus-free system by cocultivating ALV-B Env-expressing cells with TVB(S3)-expressing cells. Taken together, our results indicated that ALV-B-mediated apoptosis is triggered by ALV-B Env-TVB(S3) interactions.

SUBMITTER: Diaz-Griffero F 

PROVIDER: S-EPMC262550 | biostudies-other | 2003 Dec

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC6771772 | biostudies-literature
| S-EPMC8756617 | biostudies-literature
| S-EPMC5244330 | biostudies-literature
| PRJNA69615 | ENA
| S-EPMC6694804 | biostudies-literature
| S-EPMC3973669 | biostudies-literature
| S-EPMC23555 | biostudies-literature
| S-EPMC3979936 | biostudies-literature
| S-EPMC7597685 | biostudies-literature
| S-EPMC5810008 | biostudies-literature