Ontology highlight
ABSTRACT:
SUBMITTER: Nilsson J
PROVIDER: S-EPMC2635557 | biostudies-other | 2008 Dec
REPOSITORIES: biostudies-other
Nature cell biology 20081109 12
The spindle assembly checkpoint (SAC) is required to block sister chromatid separation until all chromosomes are properly attached to the mitotic apparatus. The SAC prevents cells from entering anaphase by inhibiting the ubiquitylation of cyclin B1 and securin by the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase. The target of the SAC is the essential APC/C activator Cdc20. It is unclear how the SAC inactivates Cdc20 but most current models suggest that Cdc20 forms a stable compl ...[more]