Ontology highlight
ABSTRACT:
SUBMITTER: Xu L
PROVIDER: S-EPMC2635802 | biostudies-other | 2009 Feb
REPOSITORIES: biostudies-other
Xu Lijuan L Xiao Nengming N Liu Feng F Ren Hongwei H Gu Jun J
Proceedings of the National Academy of Sciences of the United States of America 20090121 5
gC1qR is one of the C1q receptors implicated in the regulation of innate and adaptive immunity. We found that gC1qR inhibits RIG-I and MDA5-dependent antiviral signaling. Double stranded RNA and virus trigger the translocation of gC1qR to the mitochondrial outer membrane leading to the interaction of gC1qR with the RIG-I and MDA5 adaptor, VISA/MAVS/IPS-1/Cardif. The interaction of gC1qR with VISA/MAVS/IPS-1/Cardif at mitochondria results in the disruption of RIG-I and MDA5 signaling and the prom ...[more]