Ontology highlight
ABSTRACT:
SUBMITTER: Miyazaki D
PROVIDER: S-EPMC2638875 | biostudies-other | 2009 Feb
REPOSITORIES: biostudies-other
Miyazaki Dai D Nakamura Takao T Ohbayashi Masaharu M Kuo Chuan Hui CH Komatsu Naoki N Yakura Keiko K Tominaga Takeshi T Inoue Yoshitsugu Y Higashi Hidemitsu H Murata Meguru M Takeda Shuzo S Fukushima Atsuki A Liu Fu-Tong FT Rothenberg Marc E ME Ono Santa Jeremy SJ
International immunology 20090115 2
The immune response is regulated, in part, by effector cells whose activation requires multiple signals. For example, T cells require signals emanating from the T cell antigen receptor and co-stimulatory molecules for full activation. Here, we present evidence indicating that IgE-mediated hypersensitivity reactions in vivo also require cognate signals to activate mast cells. Immediate hypersensitivity reactions in the conjunctiva are ablated in mice deficient in eotaxin-1, despite normal numbers ...[more]