Ontology highlight
ABSTRACT:
SUBMITTER: Hoch NE
PROVIDER: S-EPMC2643984 | biostudies-other | 2009 Feb
REPOSITORIES: biostudies-other
Hoch Nyssa E NE Guzik Tomasz J TJ Chen Wei W Deans Tenecia T Maalouf Samer A SA Gratze Petra P Weyand Cornelia C Harrison David G DG
American journal of physiology. Regulatory, integrative and comparative physiology 20081210 2
The adaptive immune response and, in particular, T cells have been shown to be important in the genesis of hypertension. In the present study, we sought to determine how the interplay between ANG II, NADPH oxidase, and reactive oxygen species modulates T cell activation and ultimately causes hypertension. We determined that T cells express angiotensinogen, the angiotensin I-converting enzyme, and renin and produce physiological levels of ANG II. AT1 receptors were primarily expressed intracellul ...[more]