Ontology highlight
ABSTRACT:
SUBMITTER: Juskowiak GL
PROVIDER: S-EPMC2646870 | biostudies-other | 2008 Sep-Oct
REPOSITORIES: biostudies-other
Juskowiak Gary L GL McGee Christopher J CJ Greaves John J Van Vranken David L DL
Journal of combinatorial chemistry 20080726 5
Cysteine-rich peptides are valued as tags for biarsenical fluorophores and as environmentally important reagents for binding toxic heavy metals. Due to the inherent difficulties created by cysteine, the power of one-bead one-compound (OBOC) libraries has never been applied to the discovery of short cysteine-rich peptides. We have developed the first method for the synthesis, screening, and sequencing of cysteine-rich OBOC peptide libraries. First, we synthesized a heavily biased cysteine-rich OB ...[more]