Ontology highlight
ABSTRACT:
SUBMITTER: Di Santo R
PROVIDER: S-EPMC2646871 | biostudies-other | 2008 Aug
REPOSITORIES: biostudies-other
Journal of medicinal chemistry 20080723 15
Novel quinolinonyl diketo acids were designed to obtain integrase (IN) inhibitors selectively active against the strand transfer (ST) step of the HIV integration process. Those new compounds are characterized by a single aryl diketo acid (DKA) chain in comparison to 4, a bifunctional diketo acid reported by our group as an anti-IN agent highly potent against both the 3'-processing and ST steps. Compound 6d was the most potent derivative in IN enzyme assays, while 6i showed the highest potency ag ...[more]