Ontology highlight
ABSTRACT:
SUBMITTER: Cheng F
PROVIDER: S-EPMC2647833 | biostudies-other | 2009 Mar
REPOSITORIES: biostudies-other
Cheng Fuxia F Hartmann Stefanie S Gupta Mayetri M Ibrahim Joseph G JG Vision Todd J TJ
Bioinformatics (Oxford, England) 20090115 5
<h4>Motivation</h4>Full-length DNA and protein sequences that span the entire length of a gene are ideally used for multiple sequence alignments (MSAs) and the subsequent inference of their relationships. Frequently, however, MSAs contain a substantial amount of missing data. For example, expressed sequence tags (ESTs), which are partial sequences of expressed genes, are the predominant source of sequence data for many organisms. The patterns of missing data typical for EST-derived alignments gr ...[more]