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Toward a dynamic approach of THA planning based on ultrasound.

ABSTRACT: The risk of dislocation after THA reportedly is minimized if the acetabular implant is oriented at 45 degrees inclination and 15 degrees anteversion with respect to the anterior pelvic plane. This reference plane now is used in computer-assisted protocols. However, this static approach may lead to postoperative instability because the dynamic variations of the pelvis influence effective cup orientation and are not taken into account in this approach. We propose an ultrasound tool to register the preoperative dynamics of the pelvis for THA planning during computer-assisted surgery. To assess this pelvic behavior and its consequences on implant orientation, we tested a new 2.5-dimensional ultrasound-based approach. The pelvic flexion was registered in sitting, standing, and supine positions in 20 subjects. The mean values were -25.2 degrees +/- 5.8 degrees (standard deviation), 2.4 degrees +/- 5.1 degrees , and 6.8 degrees +/- 3.5 degrees , respectively. The mean functional anteversion varied by 26 degrees and the mean functional inclination by 12 degrees depending on the pelvic flexion. We therefore recommend including dynamic pelvic behavior to minimize dislocation risk. The notion of a safe zone should be revisited and extended to include changes with activity.

SUBMITTER: Dardenne G

PROVIDER: S-EPMC2650058 | biostudies-other | 2009 Apr

REPOSITORIES: biostudies-other

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Project description:PurposeTo develop a high-resolution three-dimensional (3D) magnetic resonance imaging (MRI)-based treatment planning approach for uveal melanomas (UM) in proton therapy.Materials/methodsFor eight patients with UM, a segmentation of the gross tumor volume (GTV) and organs-at-risk (OARs) was performed on T1- and T2-weighted 7 Tesla MRI image data to reconstruct the patient MR-eye. An extended contour was defined with a 2.5-mm isotropic margin derived from the GTV. A broad beam algorithm, which we have called πDose, was implemented to calculate relative proton absorbed doses to the ipsilateral OARs. Clinically favorable gazing angles of the treated eye were assessed by calculating a global weighted-sum objective function, which set penalties for OARs and extreme gazing angles. An optimizer, which we have named OPT'im-Eye-Tool, was developed to tune the parameters of the functions for sparing critical-OARs.ResultsIn total, 441 gazing angles were simulated for every patient. Target coverage including margins was achieved in all the cases (V95% > 95%). Over the whole gazing angles solutions space, maximum dose (Dmax ) to the optic nerve and the macula, and mean doses (Dmean ) to the lens, the ciliary body and the sclera were calculated. A forward optimization was applied by OPT'im-Eye-Tool in three different prioritizations: iso-weighted, optic nerve prioritized, and macula prioritized. In each, the function values were depicted in a selection tool to select the optimal gazing angle(s). For example, patient 4 had a T2 equatorial tumor. The optimization applied for the straight gazing angle resulted in objective function values of 0.46 (iso-weighted situation), 0.90 (optic nerve prioritization) and 0.08 (macula prioritization) demonstrating the impact of that angle in different clinical approaches.ConclusionsThe feasibility and suitability of a 3D MRI-based treatment planning approach have been successfully tested on a cohort of eight patients diagnosed with UM. Moreover, a gaze-angle trade-off dose optimization with respect to OARs sparing has been developed. Further validation of the whole treatment process is the next step in the goal to achieve both a non-invasive and a personalized proton therapy treatment.

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Toward a dynamic approach of THA planning based on ultrasound.

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