Ontology highlight
ABSTRACT:
SUBMITTER: Tomaru Y
PROVIDER: S-EPMC2651797 | biostudies-other | 2009 Mar
REPOSITORIES: biostudies-other
Tomaru Yasuhiro Y Nakanishi Misato M Miura Hisashi H Kimura Yasumasa Y Ohkawa Hiroki H Ohta Yusuke Y Hayashizaki Yoshihide Y Suzuki Masanori M
Nucleic acids research 20090107 4
Transcriptional regulation by transcriptional regulatory factors (TRFs) of their target TRF genes is central to the control of gene expression. To study a static multi-tiered inter-TRF regulatory network in the human hepatoma cells, we have applied a Matrix RNAi approach in which siRNA knockdown and quantitative RT-PCR are used in combination on the same set of TRFs to determine their interdependencies. This approach focusing on several liver-enriched TRF families, each of which consists of stru ...[more]