Ontology highlight
ABSTRACT:
SUBMITTER: Yu C
PROVIDER: S-EPMC2657816 | biostudies-other | 2009 Apr
REPOSITORIES: biostudies-other
Yu Chang C Zhang Sanguo S Zhou Chuan C Sile Saba S
Genetic epidemiology 20090401 3
Testing Hardy-Weinberg equilibrium (HWE) in the control group is commonly used to detect genotyping errors in genetic association studies. We propose a likelihood ratio test for testing HWE in the study population using both case and control samples. This test incorporates underlying association models. Another feature is that, when we infer the disease-genotype association, we explicitly incorporate HWE or a possible departure from Hardy-Weinberg equilibrium (DHWE) into the model. Our unified f ...[more]