Ontology highlight
ABSTRACT:
SUBMITTER: Naylor E
PROVIDER: S-EPMC2659327 | biostudies-other | 2009 Apr
REPOSITORIES: biostudies-other
Naylor Edmund E Arredouani Abdelilah A Vasudevan Sridhar R SR Lewis Alexander M AM Parkesh Raman R Mizote Akiko A Rosen Daniel D Thomas Justyn M JM Izumi Minoru M Ganesan A A Galione Antony A Churchill Grant C GC
Nature chemical biology 20090222 4
Research into the biological role of the Ca(2+)-releasing second messenger NAADP (nicotinic acid adenine dinucleotide phosphate) has been hampered by a lack of chemical probes. To find new chemical probes for exploring NAADP signaling, we turned to virtual screening, which can evaluate millions of molecules rapidly and inexpensively. We used NAADP as the query ligand to screen the chemical library ZINC for compounds with similar three-dimensional shape and electrostatic properties. We tested the ...[more]