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Pneumococcal serotypes and mortality following invasive pneumococcal disease: a population-based cohort study.


ABSTRACT: BACKGROUND: Pneumococcal disease is a leading cause of morbidity and mortality worldwide. The aim of this study was to investigate the association between specific pneumococcal serotypes and mortality from invasive pneumococcal disease (IPD). METHODS AND FINDINGS: In a nationwide population-based cohort study of IPD in Denmark during 1977-2007, 30-d mortality associated with pneumococcal serotypes was examined by multivariate logistic regression analysis after controlling for potential confounders. A total of 18,858 IPD patients were included. Overall 30-d mortality was 18%, and 3% in children younger than age 5 y. Age, male sex, meningitis, high comorbidity level, alcoholism, and early decade of diagnosis were significantly associated with mortality. Among individuals aged 5 y and older, serotypes 31, 11A, 35F, 17F, 3, 16F, 19F, 15B, and 10A were associated with highly increased mortality as compared with serotype 1 (all: adjusted odds ratio >or=3, p<0.001). In children younger than 5 y, associations between serotypes and mortality were different than in adults but statistical precision was limited because of low overall childhood-related mortality. CONCLUSIONS: Specific pneumococcal serotypes strongly and independently affect IPD associated mortality.

SUBMITTER: Harboe ZB 

PROVIDER: S-EPMC2680036 | biostudies-other | 2009 May

REPOSITORIES: biostudies-other

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Pneumococcal serotypes and mortality following invasive pneumococcal disease: a population-based cohort study.

Harboe Zitta B ZB   Thomsen Reimar W RW   Riis Anders A   Valentiner-Branth Palle P   Christensen Jens Jørgen JJ   Lambertsen Lotte L   Krogfelt Karen A KA   Konradsen Helle B HB   Benfield Thomas L TL  

PLoS medicine 20090526 5


<h4>Background</h4>Pneumococcal disease is a leading cause of morbidity and mortality worldwide. The aim of this study was to investigate the association between specific pneumococcal serotypes and mortality from invasive pneumococcal disease (IPD).<h4>Methods and findings</h4>In a nationwide population-based cohort study of IPD in Denmark during 1977-2007, 30-d mortality associated with pneumococcal serotypes was examined by multivariate logistic regression analysis after controlling for potent  ...[more]

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