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Catalytic C-H amination for the preparation of substituted 1,2-diamines.

ABSTRACT: Rhodium-catalyzed C-H insertion of hydroxylamine-derived sulfamate esters makes possible the synthesis of unique oxathiadiazinane heterocycles, which upon mild reduction furnish differentially substituted 1,2-diamine products. This highly chemo- and diastereoselective transformation underscores the power of catalytic C-H functionalization as a general approach to C-N bond construction.

SUBMITTER: Olson DE

PROVIDER: S-EPMC2680474 | biostudies-other | 2008 Aug

REPOSITORIES: biostudies-other

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Catalytic C-H amination for the preparation of substituted 1,2-diamines.

Olson David E DE Du Bois J J

Journal of the American Chemical Society 20080805 34

Rhodium-catalyzed C-H insertion of hydroxylamine-derived sulfamate esters makes possible the synthesis of unique oxathiadiazinane heterocycles, which upon mild reduction furnish differentially substituted 1,2-diamine products. This highly chemo- and diastereoselective transformation underscores the power of catalytic C-H functionalization as a general approach to C-N bond construction. ...[more]

PMID: 18680286

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