Ontology highlight
ABSTRACT:
SUBMITTER: Fluhrer R
PROVIDER: S-EPMC2682845 | biostudies-other | 2009 May
REPOSITORIES: biostudies-other
The Journal of biological chemistry 20090203 21
Intramembrane-cleaving proteases are required for reverse signaling and membrane protein degradation. A major class of these proteases is represented by the GXGD-type aspartyl proteases. GXGD describes a novel signature sequence that distinguishes these proteases from conventional aspartyl proteases. Members of the family of the GXGD-type aspartyl proteases are the Alzheimer disease-related gamma-secretase, the signal peptide peptidases and their homologs, and the bacterial type IV prepilin pept ...[more]